“Silent Monks Sing the Hallelujah Chorus”

January 15, 2020, 7:36 am

Perhaps a couple weeks late, but too good not to mention:

Credited to the South Kitsap High School vocal group in Port Orchard, Washington.

Hat tip: Behind the Black.


Cost to develop one new drug

January 13, 2020, 7:00 am

Federal Trade Commission Building in Washington, DC. Image courtesy of Adobe Stock.

How much does it cost for a pharmaceutical company to get one new drug onto the market? As with all variations of “what does it cost” questions the answer is complicated. Any such answer requires explanation of what the calculation means.

Other posts discussing this issue:

According to a 2016 study by Tufts Center for the Study of Drug Development, here is their calculation of what it takes to get one compound to the point of where it is approved for sale:

  • $1.395 billion – out-of-pocket costs – actual cash expended at the point approval is obtained to sell the compound
  • +$1.163 billion – “time costs”, in other words the capitalization of having to invest more than a billion dollars over many years – this represents the opportunity cost of having otherwise been able to invest that money in something else that would have produced a return earlier
  • =$2.558 billion – total capitalized cost at point of receiving approval to sell one compound
  • +0.312 billion – costs incurred for follow-up required by FDA as a condition of obtaining approval – this includes factors such as monitoring long-term side effects, monitoring safety, looking at new formulations or dosage strength
  • =$2.870 billion – total lifecycle costs to develop one new medicine that is approved by the FDA for sale

The study was based on a random selection of 106 drugs from 10 pharmaceutical companies. Since that is a random selection presumably the calculation would apply to all medicines.

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Additional sentencing, plea deals, and charges in college admissions scandal

October 28, 2019, 8:39 am

Entrance to the University of Southern California. Image courtesy of Adobe Stock.

In the last week and a half, there have been two more parents sentenced with four entering plea deals.  Additional charges have been brought against parents who are still fighting the charges.

One parent released

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Six more parents sentenced in “Varsity Blues” admissions scandal.

October 17, 2019, 4:04 pm

Residence of Felicity Huffman for the next 14 days: Federal Correctional Institution_Dublin California Overhead View by Prison Insight is licensed under CC BY 2.0

That makes #4 through #9 that have been sentenced.

First of the parents has reported for her free federal housing.

Other articles:

10/15/19 – NPR – Felicity Huffman Begins 14-Day Prison Term in College Admissions Scandal – She reported early for her 14 day sentence.

On 10/16/19, the Bureau of Prisons Inmate Locator website shows her with register 77806-112, located at Dublin FCI, with release date of 10/27/19.  That means she would have actually reported on 10/13/19, I think.  Dublin FCI is low security federal institution with an adjacent low security satellite camp. It is located in Alameda county, California.  See overhead photo above.

10/15/19 – Wall Street Journal – In College-Admissions Case, Lawyers for Coaches, Others Move to Dismiss Charges – A number of parents are filing motions that the conspiracy charges are cast too wide, including parents who weren’t participating with anyone, thus the charges are more severe than they ought to be. I don’t understand the purpose of the argument, but appears to be effort to separate some of the less-involved parents from the taint of being publicly associated with the more severe cases.

Details of sentencing

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Second and third parent sentenced in “Varsity Blues” admissions scandal.

September 26, 2019, 11:17 am

Image courtesy of Adobe Stock.

Two more parents have been sentenced in the admissions scheming. Also, the judge handling 10 plea deals outlines the rationale for sentencing.

Los Angeles Times – 9/23/19 – Prosecutors in college admissions scandal fighting for prison time for parents. The judge scheduled to sentence 10 more parents in the “Varsity Blues” admissions fiasco decided on the basis for which she will determine sentences.  Prosecutors had sought to use the amount of money paid as guiding the sentence. Judge decided the actions of the parents will guide her sentencing.

Two new sentencings

9/27/19 – Stephen Semprevivo – Sentenced to 4 months in jail, 2 years supervised release, 500 hours community service, $100,000 fine, possible restitution to Georgetown. He allegedly paid $400,000 to the fake charity, which in turn allegedly paid the Georgetown tennis coach. Plan was to present the son as a competitive tennis player.

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Admissions scandal sentencing. Data base on accused parents.

September 19, 2019, 7:29 am

USC library. USC is the most popular school for those accused in the Varsity Blues scandal. Image courtesy of Adobe Stock.

A second sentence has been handed down in the “Varsity Blues” college-admissions scandal. I’ll make a completely wild guess on what the sentencing might hint for others facing sentencing or trial. Another parent has been charged.

Finally, link to a database from Wikipedia of the accused parents, their background, number of children involved, and name of school.

Of note to readers of this blog is that I’ve not seen any comments that  implicate any of the schools beyond some of their staff doing under the table deals.

7/9/19 – Stanford sailing coach – Sentenced to 1 day in jail, 6 months house detention, 2 years supervised release, and $10K fine. Prosecution sought 1 year. This is described as the least severe of the cases since the coach didn’t receive any money directly and only one student was admitted.

9/13/19 – Felicity Huffman – Sentenced to 14 days in jail, yes 14 days, one year supervised release, 250 hours community service and $30,000 fine. Prosecutors asked for 30 days, one year supervised release, and $20K fine.

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Looks like the scope of the guardianship-transfer-for-financial-aid fiasco is growing

August 12, 2019, 1:11 pm

Image courtesy of Adobe Stock.

The first reports of a new college admissions scandal indicated the scheme was in play in Illinois. A small number of minutes research on the ol’ net shows the scandal is now open in Missouri.

With a sinking feeling, I am wondering where else this will show itself.

Scheme reportedly exists in Missouri

Kansas City Star – 8/5/19 – Did rich Missouri families give up custody of kids to get college aid? How’s that legal? Cases have been found of families in Missouri transferring guardianship of children in order to get financial aid.

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